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Endotoxemia usually occurs as a result of another illness, and these illnesses can be divided into two categories: intestinal events and non-intestinal events. By far the most common cause of endotoxemia in adult horses, intestinal events such as colic or colitis cause a break in the intestinal barrier and permit endotoxin to leak into the bloodstream. Non-intestinal events that can result in the release of endotoxins into the bloodstream include a bacterial infection in the blood (septicemia), retained placenta in mares post-foaling, and respiratory disease such as pneumonia.
Rolling and repeatedly lying down and getting up are two signs that your horse could be experiencing colic.