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Glyco-Flex III

Vetri-Science Laboratories of Vermont — Item #12928
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GLYCO-FLEX III provides maximum support for joint function and connective tissue health in dogs with severe joint dysfunction.

GLYCO-FLEX III represents the third stage of a comprehensive stage of life program for joint support and to promote long term mobility. Glyco-Flex III is also recommended by veterinarians for geriatric and retired working and sporting dogs as well as a follow-up to orthopedic surgery. 1000 mg Glucosamine HCl, 1000 mg MSM, 600 mg Perna canaliculus Mussel. Chicken flavor.

For dogs under 31 lbs, we suggest Glyco-Flex II for Cats and Small Dogs.

Click here to view our Canine Joint Product Comparison Chart.

What is a Canine SmartPak?

Build your dog's perfect SmartPak!


  • Glucosamine HCl
    1000 mg
  • Methylsulfonylmethane (MSM)
    1000 mg
  • Perna canaliculus (Green-Lipped) Mussel
    600 mg
  • N,N-Dimethylglycine HCl (DMG)
    100 mg
  • Vitamin E
    50 IU
  • Calcium Ascorbate (Vitamin C)
    30 mg
  • Manganese (as Amino Acid Chelate)
    10 mg
  • Grape Seed Extract
    5 mg
  • L-Glutathione
    2 mg
  • Selenium
    0.002 mg
brewers yeast, cellulose, dicalcium phosphate, silicon dioxide, natural imitation roast chicken flavor, stearic acid


Instructions for Use:
Label Feeding Instructions:
Initial (4-6 weeks)
Up to 30 lbs - 1/2 tablet daily
31-60 lbs - 1 tablet daily
61-100 lbs - 2 tablets daily
101 lbs and over - 2 1/2 tablets daily

Up to 30 lbs - 1/2 tablet every other day
31-60 lbs - 1/2 tablet daily
61-100 lbs - 1 tablet daily
101 lbs and over - 1 1/2 tablets daily

Clinical Research

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    92% of customers would recommend this product to a friend!
    Tell us what you think!

    The reviews provided on this website represent the experience of the individual posting the review. We do not adopt, edit, or endorse any of the submissions posted within the reviews section. Rather, the reviews are part of an online community of animal owners that desire to share their particular experience with other individuals. These reviews are not a substitute for discussing the health of your animal with a veterinarian.

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    Glyco-Flex III is rated 4.5 out of 5 by 37.
    Rated 5 out of 5 by from It's a Miracle! 2 winters ago, our mastiff's arthritis was so bad that we had to carry her up the stairs, despite lots of trips to the vet, lots of medicines, and lots of $$$$. 2 friends recommended that I try Glyco-Flex III. I was skeptical because we had spent so much money on prescription medication, I really didn't think a supplement would work. After 2 weeks on the "load" plan, our dog could go up the stairs by herself. After a month or so, she was actually running. If you're wondering whether or not you should try this product, my recommendation is YES, YES, YES!
    Date published: 2012-07-20
    Rated 4 out of 5 by from Some improvement This product is somewhat helpful for my dog. She had a torn ACL and surgery about 4 years ago. She still gets extremely stiff with more strenuous exercise exercise and I am going to try another product. My daughter, however gives it to her 10-year old mix breed dog who is a big girl, probably part German Shepherd and it has helped her hips quite a bit. Overall I think this is a good product.
    Date published: 2012-03-01
    Rated 1 out of 5 by from Apparently unpleasant taste None of my 5 dogs will eat these chewable tablets without putting them in pill pockets. I have not had this issue with other chewable joint supplements.I purposely bought a chewable joint supplement to avoid using pill pockets so for me these have not been a good value at all.
    Date published: 2012-02-11
    Rated 5 out of 5 by from Excellent Results This was highly recommended to me by a veterinary surgeon. I have 2 older, arthritic dogs and this has changed their daily mobility and comfort level remarkably. They are fussy about eating it without a nice coating of something yummy.
    Date published: 2012-01-20
    Rated 3 out of 5 by from Good product I have an 8y/o Shepard mix who tore the ligaments in both knees, and has very bad arthritis. At his last check up, the vet was concerned that he was in pain, and said if he was a human he would be a crotchety old man that would beat people with his cane. My dog has an insanely high tolerance for pain, and was not showing ANY signs of discomfort. I started him on this product, but will have to wait till the next set of x-rays to see if it is actually helping. At that point I may change my rating.
    Date published: 2011-08-10
    Rated 5 out of 5 by from It's Working My 11-year-old English Springer Spaniel has been on Glycoflex III for almost four years now. She is still competing in agility competitions and has not slowed down a bit. I credit Glycoflex III with helping her stay healthy and active!
    Date published: 2011-05-25
    Rated 4 out of 5 by from Good product... But my dog hates it! It's ok, I crush it up and put it in a bit of wet food and he eats it fine. The first 2 days he ate it w/ no problem, but then he refused it (even w/ peanut butter on it). I think it may be a bit chalky tasting for him. So far, I think it's helping his join pain. :) I totally recommended this product.
    Date published: 2011-02-03
    Rated 4 out of 5 by from It's Early Days.but Our 12 year old white golden retriever has been suffering from very bad hips and finding it very difficult to get up from a lying position. Previous products, including Vet prescriptions were not working so we decided to give GLYCO-FLEX III a try and although it's early days her daily walk has increased from 100 Yds. total to well over a 300 Yds. in less than a month and she seems to be without pain. We are giving her 2 tablets a day along with the HylaMotion Gel and a 375mg Asprin.
    Date published: 2011-02-01
    Rated 5 out of 5 by from great product I have a 3 legged German Shep. that has only one foreleg and also injured her hips and this product really helps her. We had her on glycoflex II but she needed something stronger.
    Date published: 2011-01-11
    Rated 5 out of 5 by from This really works! My Corgi mix has had ACL repairs on both back legs. The first surgery, at age 4, took a couple of months to recover from. The second leg, operated on when he was 6, healed incredibly quickly. He was totally mobile in a couple of weeks. He rebounded from the surgery much quicker the second time because he'd been on Glycoflex 3 for two years. Our vet gives the product raves.
    Date published: 2010-11-23
    Rated 4 out of 5 by from Good Product My dog went on this after tearing her ACL and undergoing surgery to repair it per the surgeon's instructions. She was on Cosequin before that and we switched her back to it. Not only does she seem to do better on the Cosequin, but the GlycoFlex contains shellfish and the odor is enough for her to refuse to eat these tablets. They're also quite large compared to the Cosequin making them even more difficult to feed.
    Date published: 2010-08-02
    Rated 5 out of 5 by from glyco flex this product is great.my 14 year old is responding well.
    Date published: 2010-08-02
    Rated 5 out of 5 by from It really works I used Glyco Flex II and just switched; it took a few weeks, but noticed my dog is moving better and seems more comfortable.
    Date published: 2010-06-01
    Rated 5 out of 5 by from Great Product We started using Glyco-Flex III when our Golden Retriever was nine and started showing some arthritis in her knee joints and back. She is now 14 and, although she is slowing down, I do think this product has kept her active. We have added in some yearly series of joint injections, but this product has been her main-stay.
    Date published: 2010-05-06
    Rated 5 out of 5 by from Great Product I have tried many glucosamine supplements for german shepherd, who has severe hip dysplasia, with little results. Cosequin worked for a month and then he seemed to revert back to before. However, the Glycoflex III has him running around with little signs of lameness. He will take his pills in his food or as a treat without hesitation. I could not have asked for a better product and I will continue using this for years to come.
    Date published: 2010-04-05
    Rated 5 out of 5 by from Really Works! I started our dog, Rosie, on Glycoflex 3 about 2 weeks ago. She is a German Shepherd/Australian Shepherd cross and has progressive arthritis in her spine. Even on her pain meds, she just wanted to lay around and was sore. Now, she is back playing and is much, much happier. We plan to drop back her pain meds a bit (hard on stomach). She also doesn't mind eating these which is a treat as Rosie is terrible to give meds to. For a big dog, she is very delicate with her eating and can eat cheese or meat off a pill very neatly. It's great to have our "floofy" (fluffy goof) back.
    Date published: 2010-02-23
    Rated 5 out of 5 by from Great product Our 14 year old Lab has arthritis in one knee related to a torn ACL from years ago. She used to have to get her confidence up to jump up a six inch step into our house. Using Glyco-Flex III for a few months now and she has no trouble with that step. Not only that, but she jumps and runs all over the place again. I wish it was a little less expensive, but it matches very well price-wise with products of similar quality.
    Date published: 2010-01-11
    Rated 5 out of 5 by from Very pleased with this purchase of Glyco-Flex 111 I give this product to both my dogs and they look forward to eating it, they think it is a treat! Also I have noticed an improvement in my 12 yr. old lab. He is able to move his back leg much better than before and does not seem to have the discomfort he had before this product. I have not used it very long either so I know that over time he will continue to improve. My younger dog had spinal surgery 2 yrs. ago and his legs in the back are much improved. He has arthritus. I am very pleased and also very pleased with Smart Pak service and quality of their products and will continue to use them for all my needs, or should I say all my dogs needs.
    Date published: 2009-12-22
    Rated 4 out of 5 by from Great product but not for fussy eaters Glyco Flex lll is a great product and my vet really likes it but my male German Shepherd, a very fussy eater, would not eat it even if disguised with other foods (baby food chicken, etc.) My female Shephed would eat it happily, but she doesn't need it! A Smart Pack representative is very kindly sending me samples of another product that she thinks would be more palatable, so we shall see! I think the problem is the perna mussel -- fishy. I would recommend it with qualifications -- described above.
    Date published: 2009-12-07
    Rated 5 out of 5 by from It works! I have 2 "senior" dogs (Lab and Aussie) who were "slowing" down-no running or jumping. 6 weeks later, they are running, playing and jumping on the couch again!!!
    Date published: 2009-10-21
    Rated 4 out of 5 by from This supplement really helps with my dogs arthritis she's even jumping into the bed again. However, she dosen't seem to like to eat it and we sometimes have to coax her into it.
    Date published: 2009-10-15
    Rated 4 out of 5 by from solid product Rusty is the second large dog I've maintained on Glyco-Flex III. It has made a big difference in his mobility. He gets up more easily, and can almost keep up with my Standard Poodle on a sprint to the barn. The only negative is Rusty won't readily eat the tablets (doesn't like the taste?) so I have to crumble them up in his food.
    Date published: 2009-07-15
    Rated 5 out of 5 by from I'm amazed! About a year ago, someone dumped two full blooded labs on our property. Our black lab, Belle, was about two, and our yellow lab, Beau, was about 6. Both seemed in relatively good health, though both were pretty fat, and they were really well trained. Beau was incredibly stiff, could barely move. We knew a lot of it was his extra weight (The vet told us he needed to lose at least 15 lbs), but some of it was also hip dysplasia, prevalent in the breed. I tried other joint supplements, but I wasn't very happy with the results. I also put him on a diet food, and after loosing 10 lbs he's a much happier, more mobile dog. Still, though, he was stiff, and limped quite a bit. So finally, roughly two months ago, I decided to try Glyco-Flex...and what a difference! I've never seen him move so well! He's able to swim now, and play with his younger sister. And, for the first time since we got him, he's able to RUN! It's incredible! Thank you for a wonderful product! And it's definitely worth trying.
    Date published: 2009-06-09
    Rated 5 out of 5 by from Our Collie Loves It! Out Collie has severe problems with all he shoulders and without Glyco-Flex III she has problems walking. With this product, she not only walks well, but plays, climbs stairs, and acts like a much younger dog. We are very happy to find this product for her since she's much happier with it than without.
    Date published: 2009-05-10
    Rated 5 out of 5 by from Great Relief For A Sore Dog! We have been using this product for about 2 years now and it has brought relief for our 15 year old Vizsla, Lucy. She had an accident a few years back that caused her to lose all of the joint tissue in her left front leg. While she still limps and due to age, has severe arthritis, she is still able to get up and enjoy life. We are so thankful our vet recommended giving this a try, it really helps!!!!!!!
    Date published: 2009-04-16
    Rated 5 out of 5 by from Works Great! Our 80 lb. Boxer is getting older and the vet advised us to monitor his activity, but with this product he does well and can join us for most any activity.
    Date published: 2009-04-15
    Rated 5 out of 5 by from My dog can move This product has allowed my dog to continue on trail rides, even with hip dysplasia. Without this product, even stairs are too much of an obstacle.
    Date published: 2009-04-14
    Rated 5 out of 5 by from great product Our 120 lb lab/mastiff had been taking an all-purpose suppliment with glucosamine only for a few years, but this winter he was stiff and limping from hip displasia. We switched to Glyco-Flex III a few weeks ago. I am very happy to say the big dog has shown a vast improvement. He's still slow out of the gate, but once warmed up he gallops around happily, showing way more endurance than he has in years. And he has not limped in weeks even with the increased activity. He eats the tablets readily and has not shown any digestive upset. Thanks, Smart Pak, for making great products available. The tables and comparisons make choosing a product much easier. And of course, your customer service is the best.
    Date published: 2009-04-06
    Rated 5 out of 5 by from Excellent choice for a joint supplement! My Bullmastiff had to have surgery for OCD in both of her shoulders. My veterinarian recommended I use this product to help her recovery. Well, 3 years later she is still doing well and has not taken a lame step since her surgery. This supplement has had a significant impact on her recovery and continued joint health.
    Date published: 2007-08-27
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