Product Description

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Regu-Mate is an FDA-approved oral synthetic progesterone hormone used to prevent of estrus (heat) in mares or to control the time that estrus starts.  Wear protective gloves and follow human precautions when using.  Available in a 1000 mL bottle (each mL contains 2.2 mg of altrenogest in an oil solution).

Other Ingredients

Each mL of Regu-Mate® (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution.


Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses significantly greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia. Warning: Do not use in horses intended for food. Caution for Handlers: Skin contact must be avoided as Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. Protective gloves must be worn by all persons handling this product. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate® (altrenogest) Solution 0.22%. Women of child bearing age should exercise extreme caution when handling this product. Accidental absorption could lead to a disruption of the menstrual cycle or prolongation of pregnancy. Direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water. Information for Handlers: Warning: Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed by the skin. Skin contact must be avoided; protective gloves must be worn when handling this product. Effects of Overexposure: There has been no human use of this specific product. The information contained in this section is extrapolated from data available on other products of the same pharmacological class that have been used in humans. Effects anticipated are due to the progestational activity of altrenogest. Acute effects after a single exposure are possible; however, continued daily exposure has the potential for more untoward effects such as disruption of the menstrual cycle, uterine or abdominal cramping, increased or decreased uterine bleeding, prolongation of pregnancy and headaches. The oil base may also cause complications if swallowed. In addition, the list of people who should not handle this product (see below) is based upon the known effects of progestins used in humans on a chronic basis. People Who Should Not Handle This Product: 1. Women who are or suspect they are pregnant. 2. Anyone with thrombophlebitis or thromboembolic disorders or with a history of these events. 3. Anyone with cerebral-vascular or coronary-artery disease. 4. Women with known or suspected carcinoma of the breast. 5. People with known or suspected estrogen-dependent neoplasia. 6. Women with undiagnosed vaginal bleeding. 7. People with benign or malignant tumors which developed during the use of oral contraceptives or other estrogen-containing products. 8. Anyone with liver dysfunction or disease. Accidental Exposure: Altrenogest is readily absorbed from contact with the skin. In addition, this oil-based product can penetrate porous gloves. Altrenogest should not penetrate intact rubber or impervious gloves; however, if there is leakage (i.e. pinhole, spillage, etc.), the contaminated area covered by such occlusive materials may have increased absorption. The following measures are recommended in case of accidental exposure. Skin Exposure: Wash immediately with soap and water. Eye Exposure: Immediately flush with plenty of water for 15 minutes. Get medical attention. If Swallowed: Do not induce vomiting. Regu-Mate® (altrenogest) Solution 0.22% contains an oil. Call a physician. Vomiting should be supervised by a physician because of possible pulmonary damage via aspiration of the oil base. If possible, bring the container and labeling to the physician. Caution: For oral use in horses only. Keep this and all medication out of the reach of children. All pharmaceutical products are shipped according to the manufacturer’s guidelines. In accordance with state and federal regulations, we are unable to accept returns on any pharmaceutical items. For all expedited deliveries UPS is responsible for delivering the package on time. Certain circumstances can arise where UPS is unable to deliver expedites on time due to weather, remoteness of location, etc. All efforts will be made by SmartPak to ensure that packages arrive on time as ordered, but we cannot guarantee that UPS will always act accordingly. In particular, orders indicated for Saturday delivery cannot be guaranteed. We strongly recommend that if the order is for a particular health emergency, customers should seek immediate assistance from their vet. If a UPS expedited delivery fails to arrive on time as ordered, SmartPak will refund the additional shipping charges incurred.